@article{ChenWangLietal.2020,
  author    = {Chen, Yaping and Wang, Ji and Li, Xiangling and Hu, Ning and Voelcker, Nicolas H. and Xie, Xi and Elnathan, Roey},
  title     = {Emerging Roles of 1D Vertical Nanostructures in Orchestrating Immune Cell Functions},
  journal   = {Advanced Materials},
  volume    = {32},
  number    = {40},
  issn      = {0935-9648},
  doi       = {10.1002/adma.202001668},
  pages     = {2001668},
  year      = {2020},
  abstract  = {Abstract Engineered nano-bio cellular interfaces driven by 1D vertical nanostructures (1D-VNS) are set to prompt radical progress in modulating cellular processes at the nanoscale. Here, tuneable cell-VNS interfacial interactions are probed and assessed, highlighting the use of 1D-VNS in immunomodulation, and intracellular delivery into immune cells—both crucial in fundamental and translational biomedical research. With programmable topography and adaptable surface functionalization, 1D-VNS provide unique biophysical and biochemical cues to orchestrate innate and adaptive immunity, both ex vivo and in vivo. The intimate nanoscale cell-VNS interface leads to membrane penetration and cellular deformation, facilitating efficient intracellular delivery of diverse bioactive cargoes into hard-to-transfect immune cells. The unsettled interfacial mechanisms reported to be involved in VNS-mediated intracellular delivery are discussed. By identifying up-to-date progress and fundamental challenges of current 1D-VNS technology in immune-cell manipulation, it is hoped that this report gives timely insights for further advances in developing 1D-VNS as a safe, universal, and highly scalable platform for cell engineering and enrichment in advanced cancer immunotherapy such as chimeric antigen receptor-T therapy.},
  language  = {en}
}