TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Chen, Yaping
A1  - Wang, Ji
A1  - Li, Xiangling
A1  - Hu, Ning
A1  - Voelcker, Nicolas H.
A1  - Xie, Xi
A1  - Elnathan, Roey
T1  - Emerging Roles of 1D Vertical Nanostructures in Orchestrating Immune Cell Functions
JF  - Advanced Materials
N2  - Abstract Engineered nano–bio cellular interfaces driven by 1D vertical nanostructures (1D-VNS) are set to prompt radical progress in modulating cellular processes at the nanoscale. Here, tuneable cell–VNS interfacial interactions are probed and assessed, highlighting the use of 1D-VNS in immunomodulation, and intracellular delivery into immune cells—both crucial in fundamental and translational biomedical research. With programmable topography and adaptable surface functionalization, 1D-VNS provide unique biophysical and biochemical cues to orchestrate innate and adaptive immunity, both ex vivo and in vivo. The intimate nanoscale cell–VNS interface leads to membrane penetration and cellular deformation, facilitating efficient intracellular delivery of diverse bioactive cargoes into hard-to-transfect immune cells. The unsettled interfacial mechanisms reported to be involved in VNS-mediated intracellular delivery are discussed. By identifying up-to-date progress and fundamental challenges of current 1D-VNS technology in immune-cell manipulation, it is hoped that this report gives timely insights for further advances in developing 1D-VNS as a safe, universal, and highly scalable platform for cell engineering and enrichment in advanced cancer immunotherapy such as chimeric antigen receptor-T therapy.
Y1  - 2020
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:291:415-3059
SN  - 0935-9648
SS  - 0935-9648
U6  - https://doi.org/10.1002/adma.202001668
DO  - https://doi.org/10.1002/adma.202001668
VL  - 32
IS  - 40
SP  - 2001668
S1  - 2001668
ER  -