TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Danielsson, Frida
A1  - Peterson, McKenzie Kirsten
A1  - Caldeira Araújo, Helena
A1  - Lautenschläger, Franziska
A1  - Gad, Annica K.B.
T1  - Vimentin Diversity in Health and Disease
JF  - Cells
N2  - Vimentin is a protein that has been linked to a large variety of pathophysiological conditions, including cataracts, Crohn’s disease, rheumatoid arthritis, HIV and cancer. Vimentin has also been shown to regulate a wide spectrum of basic cellular functions. In cells, vimentin assembles into a network of filaments that spans the cytoplasm. It can also be found in smaller, non-filamentous forms that can localise both within cells and within the extracellular microenvironment. The vimentin structure can be altered by subunit exchange, cleavage into different sizes, re-annealing, post-translational modifications and interacting proteins. Together with the observation that different domains of vimentin might have evolved under different selection pressures that defined distinct biological functions for different parts of the protein, the many diverse variants of vimentin might be the cause of its functional diversity. A number of review articles have focussed on the biology and medical aspects of intermediate filament proteins without particular commitment to vimentin, and other reviews have focussed on intermediate filaments in an in vitro context. In contrast, the present review focusses almost exclusively on vimentin, and covers both ex vivo and in vivo data from tissue culture and from living organisms, including a summary of the many phenotypes of vimentin knockout animals. Our aim is to provide a comprehensive overview of the current understanding of the many diverse aspects of vimentin, from biochemical, mechanical, cellular, systems biology and medical perspectives
KW  - vimentin
KW  - intermediate filaments
KW  - cell‒extracellular matrix adhesions
KW  - extracellular vimentin
KW  - cell mechanical stiffness or elasticity
KW  - cellular contractility
KW  - biomechanics
KW  - epithelial‒mesenchymal transition
KW  - tissue regeneration
KW  - cancer and metastasis
KW  - drug target
KW  - clinical biomarkers
Y1  - 2018
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:291:415-3173
UR  - http://www.mdpi.com/2073-4409/7/10/147
SN  - 2073-4409
SS  - 2073-4409
U6  - https://doi.org/10.3390/cells7100147
DO  - https://doi.org/10.3390/cells7100147
VL  - 7
IS  - 10
SP  - 147
S1  - 147
ER  -