@article{HarfoushHannigLeetal.2020, author = {Harfoush, Shaza A. and Hannig, Matthias and Le, Duc Dung and Heck, Sebastian and Leitner, Maximilian and Omlor, Albert Joachim and Tavernaro, Isabella and Kraegeloh, Annette and Kautenburger, Ralf and Kickelbick, Guido and Beilhack, Andreas and Bischoff, Markus and Nguyen, Juliane and Sester, Martina and Bals, Robert and Dinh, Quoc Thai}, title = {High-dose intranasal application of titanium dioxide nanoparticles induces the systemic uptakes and allergic airway inflammation in asthmatic mice}, journal = {Respiratory Research}, volume = {21}, number = {1}, issn = {1465-993X}, doi = {10.1186/s12931-020-01386-0}, institution = {Nano Cell Interactions}, pages = {168}, year = {2020}, abstract = {Titanium dioxide nanoparticles (TiO2 NPs) have a wide range of applications in several industrial and biomedical domains. Based on the evidence, the workers exposed to inhaled nanosized TiO2 powder are more susceptible to the risks of developing respiratory diseases. Accordingly, this issue has increasingly attracted the researchers' interest in understanding the consequences of TiO2 NPs exposure. Regarding this, the present study was conducted to analyze the local effects of TiO2 NPs on allergic airway inflammation and their uptake in a mouse model of ovalbumin (OVA)-induced allergic airway inflammation.}, language = {en} }