@article{HarfoushHannigLeetal.2020, author = {Shaza A. Harfoush and Matthias Hannig and Duc Dung Le and Sebastian Heck and Maximilian Leitner and Albert Joachim Omlor and Isabella Tavernaro and Annette Kraegeloh and Ralf Kautenburger and Guido Kickelbick and Andreas Beilhack and Markus Bischoff and Juliane Nguyen and Martina Sester and Robert Bals and Quoc Thai Dinh}, title = {High-dose intranasal application of titanium dioxide nanoparticles induces the systemic uptakes and allergic airway inflammation in asthmatic mice}, series = {Respiratory Research}, volume = {21}, number = {1}, issn = {1465-993X}, doi = {10.1186/s12931-020-01386-0}, url = {https://nbn-resolving.org/urn:nbn:de:bsz:291:415-3555}, year = {2020}, abstract = {Titanium dioxide nanoparticles (TiO2 NPs) have a wide range of applications in several industrial and biomedical domains. Based on the evidence, the workers exposed to inhaled nanosized TiO2 powder are more susceptible to the risks of developing respiratory diseases. Accordingly, this issue has increasingly attracted the researchers’ interest in understanding the consequences of TiO2 NPs exposure. Regarding this, the present study was conducted to analyze the local effects of TiO2 NPs on allergic airway inflammation and their uptake in a mouse model of ovalbumin (OVA)-induced allergic airway inflammation.}, language = {en} }