TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Hetmanski, Joseph H.R.
A1  - de Belly, Henry
A1  - Busnelli, Ignacio
A1  - Waring, Thomas
A1  - Nair, Roshna Vakkeel
A1  - Sokleva, Vanesa
A1  - Dobre, Oana
A1  - Cameron, Angus
A1  - Gauthier, Nils
A1  - Lamaze, Christophe
A1  - del Campo Bécares, Aránzazu
A1  - Starborg, Tobias
A1  - Zech, Tobias
A1  - Goetz, Jacky G.
A1  - Paluch, Ewa K.
A1  - Schwartz, Jean-Marc
A1  - Caswell, Patrick T.
T1  - Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration
JF  - Developmental Cell
N2  - Summary In development, wound healing, and cancer metastasis, vertebrate cells move through 3D interstitial matrix, responding to chemical and physical guidance cues. Protrusion at the cell front has been extensively studied, but the retraction phase of the migration cycle is not well understood. Here, we show that fast-moving cells guided by matrix cues establish positive feedback control of rear retraction by sensing membrane tension. We reveal a mechanism of rear retraction in 3D matrix and durotaxis controlled by caveolae, which form in response to low membrane tension at the cell rear. Caveolae activate RhoA-ROCK1/PKN2 signaling via the RhoA guanidine nucleotide exchange factor (GEF) Ect2 to control local F-actin organization and contractility in this subcellular region and promote translocation of the cell rear. A positive feedback loop between cytoskeletal signaling and membrane tension leads to rapid retraction to complete the migration cycle in fast-moving cells, providing directional memory to drive persistent cell migration in complex matrices.
KW  - cell migration
KW  - cell invasion
KW  - extracellular matrix
KW  - membrane tension
KW  - durotaxis
KW  - cytoskeleton
KW  - RhoGTPase
KW  - caveolae
Y1  - 2019
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:291:415-3610
UR  - http://www.sciencedirect.com/science/article/pii/S153458071930735X
SN  - 1534-5807
SS  - 1534-5807
U6  - https://doi.org/10.1016/j.devcel.2019.09.006
DO  - https://doi.org/10.1016/j.devcel.2019.09.006
VL  - 51
IS  - 4
SP  - 460
EP  - 475
ER  -