@article{YasarBiehlDe Rossietal.2018,
  author    = {Yasar, Hanzey and Biehl, Alexander and De Rossi, Chiara and Koch, Marcus and Murgia, Xabier and Loretz, Brigitta and Lehr, Claus-Michael},
  title     = {Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles},
  journal   = {Journal of Nanobiotechnology},
  volume    = {16},
  number    = {1},
  issn      = {1477-3155},
  doi       = {10.1186/s12951-018-0401-y},
  institution = {Physical Analytics},
  pages     = {72},
  year      = {2018},
  abstract  = {Messenger RNA (mRNA) has gained remarkable attention as an alternative to DNA-based therapies in biomedical research. A variety of biodegradable nanoparticles (NPs) has been developed including lipid-based and polymer-based systems for mRNA delivery. However, both systems still lack in achieving an efficient transfection rate and a detailed understanding of the mRNA transgene expression kinetics. Therefore, quantitative analysis of the time-dependent translation behavior would provide a better understanding of mRNA's transient nature and further aid the enhancement of appropriate carriers with the perspective to generate future precision nanomedicines with quick response to treat various diseases.},
  language  = {en}
}