TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Yasar, Hanzey
A1  - Biehl, Alexander
A1  - De Rossi, Chiara
A1  - Koch, Marcus
A1  - Murgia, Xabier
A1  - Loretz, Brigitta
A1  - Lehr, Claus-Michael
T1  - Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles
JF  - Journal of Nanobiotechnology
N2  - Messenger RNA (mRNA) has gained remarkable attention as an alternative to DNA-based therapies in biomedical research. A variety of biodegradable nanoparticles (NPs) has been developed including lipid-based and polymer-based systems for mRNA delivery. However, both systems still lack in achieving an efficient transfection rate and a detailed understanding of the mRNA transgene expression kinetics. Therefore, quantitative analysis of the time-dependent translation behavior would provide a better understanding of mRNA’s transient nature and further aid the enhancement of appropriate carriers with the perspective to generate future precision nanomedicines with quick response to treat various diseases.
Y1  - 2018
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:291:415-4996
SN  - 1477-3155
SS  - 1477-3155
U6  - https://doi.org/10.1186/s12951-018-0401-y
DO  - https://doi.org/10.1186/s12951-018-0401-y
VL  - 16
IS  - 1
SP  - 72
S1  - 72
ER  -