TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Yang, Wenjuan
A1  - Denger, Andreas
A1  - Diener, Caroline
A1  - Küppers, Frederic
A1  - Soriano-Baguet, Leticia
A1  - Schäfer, Gertrud
A1  - Yanamandra Guruvenkata, Archana K.
A1  - Zhao, Renping
A1  - Knörck, Arne
A1  - Schwarz, Eva C.
A1  - Hart, Martin
A1  - Lammert, Frank
A1  - Prates Roma, Leticia
A1  - Brenner, Dirk
A1  - Christidis, Grigorios
A1  - Helms, Volkhard
A1  - Meese, Eckart
A1  - Hoth, Markus
A1  - Qu, Bin
T1  - Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand
JF  - Frontiers in immunology
N2  - TNF-related apoptosis inducing ligand (TRAIL) is expressed on cytotoxic T lymphocytes (CTLs) and TRAIL is linked to progression of diabetes. However, the impact of high glucose on TRAIL expression and its related killing function in CTLs still remains largely elusive. Here, we report that TRAIL is substantially up-regulated in CTLs in environments with high glucose (HG) both in vitro and in vivo. Non-mitochondrial reactive oxygen species, NFκB and PI3K/Akt are essential in HG-induced TRAIL upregulation in CTLs. TRAIL<sup>high</sup> CTLs induce apoptosis of pancreatic beta cell line 1.4E7. Treatment with metformin and vitamin D reduces HG-enhanced expression of TRAIL in CTLs and coherently protects 1.4E7 cells from TRAIL-mediated apoptosis. Our work suggests that HG-induced TRAIL<sup>high</sup> CTLs might contribute to the destruction of pancreatic beta cells in a hyperglycemia condition.
Y1  - 2022
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:291:415-540
U6  - https://doi.org/10.3389/fimmu.2022.831680
DO  - https://doi.org/10.3389/fimmu.2022.831680
VL  - 13
SP  - 831680
ER  -