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Light-Regulated Angiogenesis via a Phototriggerable VEGF Peptidomimetic

  • The application of growth factor based therapies in regenerative medicine is limited by the high cost, fast degradation kinetics, and the multiple functions of these molecules in the cell, which requires regulated delivery to minimize side effects. Here a photoactivatable peptidomimetic of the vascular endothelial growth factor (VEGF) that allows the light-controlled presentation of angiogenic signals to endothelial cells embedded in hydrogel matrices is presented. A photoresponsive analog of the 15-mer peptidomimetic Ac-KLTWQELYQLKYKGI-NH2 (abbreviated PQK) is prepared by introducing a 3-(4,5-dimethoxy-2-nitrophenyl)-2-butyl (DMNPB) photoremovable protecting group at the Trp4 residue. This modification inhibits the angiogenic potential of the peptide temporally. Light exposure of PQK modified hydrogels provide instructive cues to embedded endothelial cells and promote angiogenesis at the illuminated sites of the 3D culture, with the possibility of spatial control. PQK modified photoresponsive biomaterials offer an attractive approach for the dosed delivery and spatial control of pro-angiogenic factors to support regulated vascular growth by just using light as an external trigger.

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Metadaten
Document Type:Article
Author:Roshna Vakkeel NairORCiD, Aleeza FarrukhORCiD, Aránzazu del Campo BécaresORCiD
URN:urn:nbn:de:bsz:291:415-1005
DOI:https://doi.org/10.1002/adhm.202100488
Parent Title (English):Advanced Healthcare Materials
Volume:10
Issue:14
First Page:2100488
Language:English
Year of first Publication:2021
Release Date:2022/08/10
Tag:Light regulated angiogenesis; Photoactivatable QK; Photoactivatable peptides; Photocaged tryptophan; Photoresponsive hydrogels
Impact:11.092 (2021)
Research Groups:Dynamical Biomaterials
DDC classes:500 Naturwissenschaften und Mathematik / 570 Biowissenschaften, Biologie
Open Access:Open Access
Signature:INM 2021/068
Licence (German):License LogoCreative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International