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Optoacoustically induced auditory brainstem responses in the mouse model enhanced through an absorbing film

  • Significance: Optoacoustic stimulation offers an alternative stimulation strategy for the hearing organ. To serve as the base for a novel auditory prosthesis, the optoacoustic stimulation must be biocompatible and energy-saving. Aim: Enhancing the efficiency of optoacoustic stimulation while reducing the energy input in a suited animal model. Approach: Optoacoustically induced auditory brainstem responses (oABRs) were recorded after the pulsed laser irradiation of the tympanic membrane (TM) in mice. The results were compared with the ABRs induced through acoustic click stimulation. In addition, self-adhesive absorbing films were applied on the TM before the optoacoustic stimulation to investigate their effect on the resulting ABRs. Results: Using an absorbing film on the TM during optical stimulation led to considerably enhanced oABR wave I amplitude values compared with the stimulation of the bare TM. When using our stimulation strategy, we induced oABR waves in the 50% to 60% range of the acoustical stimulation reached with 80-dB SPL click stimuli. Conclusions: The mouse model can be used for certain developmental work for an optoacoustic auditory prosthesis. Using absorbing films on the TM during optical stimulation considerably enhances oABR wave I amplitude. Optimization of the stimulation strategy could further enhance the efficiency within biocompatibility margins.

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Document Type:Article
Author:Katharina SorgORCiD, Larissa HeimannORCiD, Gabriela Moreira LanaORCiD, Achim LangenbucherORCiD, Bernhard Schick, Eduard ArztORCiD, Gentiana Ioana WenzelORCiD
Parent Title (English):Journal of Biomedical Optics
First Page:098001
Year of first Publication:2021
Release Date:2022/08/16
Tag:auditory brainstem responses; laser ablation; optoacoustic; optoacoustically induced auditory brainstem responses; silicone elastomers
Impact:03.758 (2021)
Funding Information:Seventh Framework Programme (FP/2007-2013)
Research Groups:Functional Microstructures
DDC classes:500 Naturwissenschaften und Mathematik / 570 Biowissenschaften, Biologie
Open Access:Open Access
Signature:INM 2021/099
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International