Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles
- Messenger RNA (mRNA) has gained remarkable attention as an alternative to DNA-based therapies in biomedical research. A variety of biodegradable nanoparticles (NPs) has been developed including lipid-based and polymer-based systems for mRNA delivery. However, both systems still lack in achieving an efficient transfection rate and a detailed understanding of the mRNA transgene expression kinetics. Therefore, quantitative analysis of the time-dependent translation behavior would provide a better understanding of mRNA’s transient nature and further aid the enhancement of appropriate carriers with the perspective to generate future precision nanomedicines with quick response to treat various diseases.
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| Document Type: | Article |
|---|---|
| Author: | Hanzey Yasar, Alexander Biehl, Chiara De Rossi, Marcus Koch, Xabier MurgiaORCiD, Brigitta LoretzORCiD, Claus-Michael LehrORCiD |
| URN: | urn:nbn:de:bsz:291:415-4996 |
| DOI: | https://doi.org/10.1186/s12951-018-0401-y |
| ISSN: | 1477-3155 |
| Parent Title (English): | Journal of Nanobiotechnology |
| Volume: | 16 |
| Issue: | 1 |
| Pagenumber: | 72 |
| Language: | English |
| Year of first Publication: | 2018 |
| Release Date: | 2022/11/18 |
| Impact: | 05.345 (2018) |
| Research Departments: | Physikalische Analytik |
| Researchfields: | Servicebereich |
| Open Access: | Open Access |
| Signature: | INM 2018/097 |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
