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Lighting the Path: Light Delivery Strategies to Activate Photoresponsive Biomaterials In Vivo

  • Photoresponsive biomaterials are experiencing a transition from in vitro models to in vivo demonstrations that point toward clinical translation. Dynamic hydrogels for cell encapsulation, light-responsive carriers for controlled drug delivery, and nanomaterials containing photosensitizers for photodynamic therapy are relevant examples. Nonetheless, the step to the clinic largely depends on their combination with technologies to bring light into the body. This review highlights the challenge of photoactivation in vivo, and presents strategies for light management that can be adopted for this purpose. The authors’ focus is on technologies that are materials-driven, particularly upconversion nanoparticles that assist in “direct path” light delivery through tissue, and optical waveguides that “clear the path” between external light source and in vivo target. The authors’ intention is to assist the photoresponsive biomaterials community transition toward medical technologies by presenting light delivery concepts that can be integrated with the photoresponsive targets. The authors also aim to stimulate further innovation in materials-based light delivery platforms by highlighting needs and opportunities for in vivo photoactivation of biomaterials.

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Document Type:Article
Author:Samuel Pearson, Jun Feng, Aránzazu del Campo BécaresORCiD
Parent Title (English):Advanced Functional Materials
First Page:2105989
Year of first Publication:2021
Release Date:2022/08/10
Tag:biomaterials; photoactivation; photoresponsive; upconversion nanoparticles; waveguides
Impact:19.924 (2021)
Funding Information:European Union's Horizon 2020 research and innovation program. Grant Number: 731957; European Commission. Grant Number: FET PROACTIVE 731957; China Scholarship Council
Scientific Units:Dynamical Biomaterials
DDC classes:500 Naturwissenschaften und Mathematik / 570 Biowissenschaften, Biologie
Open Access:Open Access
Signature:INM 2021/106
Licence (German):License LogoCreative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International