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Reliable release testing for nanoparticles with the NanoDis System, an innovative sample and separate technique

  • One of the critical quality attributes of nanoparticle formulations is drug release. Their release properties should therefore be well characterized with predictive and discriminative methods. However, there is presently still no standard method for the release testing of extended release nanoformulations. Dialysis techniques are widely used in the literature but suffer from severe drawbacks. Burst release of formulations can be masked by slow permeation kinetics of the free drug through the dialysis membrane, saturation in the membrane, and absence of agitation in the membrane. In this study, the release profile of poly(lactic co-glycolic) (PLGA) nanocapsules loaded with all-trans retinoic acid was characterized using an innovative sample and separate set-up, the NanoDis System, and compared to the release profile measured with a dialysis technique. The NanoDis System showed clear superiority over the dialysis method and was able to accurately characterize the burst release from the capsules and furthermore discriminate between different all-trans retinoic acid nanoparticle formulations.

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Document Type:Article
Author:Sonia M. LombardoORCiD, Nazende Günday TüreliORCiD, Marcus Koch, Marc SchneiderORCiD, Akif E. Türeli
Parent Title (English):International Journal of Pharmaceutics
First Page:121215
Year of first Publication:2021
Release Date:2022/08/13
Tag:PLGA nanocapsules; dialysis; nanoparticles; release testing; retinoic acid
Impact:06.510 (2021)
Funding Information:European Union's Horizon 2020 research and innovation programme under grant agreement No 764958.
Groups:Physikalische Analytik
DDC classes:500 Naturwissenschaften und Mathematik / 570 Biowissenschaften, Biologie
Open Access:Open Access
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International