Effectiveness of porous silicon nanoparticle treatment at inhibiting the migration of a heterogeneous glioma cell population
- Approximately 80% of brain tumours are gliomas. Despite treatment, patient mortality remains high due to local metastasis and relapse. It has been shown that transferrin-functionalised porous silicon nanoparticles (Tf@pSiNPs) can inhibit the migration of U87 glioma cells. However, the underlying mechanisms and the effect of glioma cell heterogeneity, which is a hallmark of the disease, on the efficacy of Tf@pSiNPs remains to be addressed.
| Document Type: | Article |
|---|---|
| Author: | Youssef Abdalla, Meihua LuoORCiD, Ermei Mäkilä, Bryan W. DayORCiD, Nicolas H. VoelckerORCiD, Wing Yin Tong |
| URN: | urn:nbn:de:bsz:291:415-1132 |
| DOI: | https://doi.org/10.1186/s12951-021-00798-4 |
| Parent Title (English): | Journal of Nanobiotechnology |
| Volume: | 19 |
| Issue: | 1 |
| First Page: | 60 |
| Language: | English |
| Year of first Publication: | 2021 |
| Release Date: | 2022/08/14 |
| Tag: | cell migration; glioblastoma; glioma; silicon nanoparticles; transferrin |
| Impact: | 09.429 (2021) |
| Funding Information: | Commonwealth Scientific and Industrial Research Organisation (CSIRO) |
| DDC classes: | 600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin, Gesundheit |
| Open Access: | Open Access |
| Signature: | INM 2021/030 |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
