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Effectiveness of porous silicon nanoparticle treatment at inhibiting the migration of a heterogeneous glioma cell population

  • Approximately 80% of brain tumours are gliomas. Despite treatment, patient mortality remains high due to local metastasis and relapse. It has been shown that transferrin-functionalised porous silicon nanoparticles (Tf@pSiNPs) can inhibit the migration of U87 glioma cells. However, the underlying mechanisms and the effect of glioma cell heterogeneity, which is a hallmark of the disease, on the efficacy of Tf@pSiNPs remains to be addressed.

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Document Type:Article
Author:Youssef Abdalla, Meihua LuoORCiD, Ermei Mäkilä, Bryan W. DayORCiD, Nicolas H. VoelckerORCiD, Wing Yin Tong
Parent Title (English):Journal of Nanobiotechnology
First Page:60
Year of first Publication:2021
Release Date:2022/08/14
Tag:cell migration; glioblastoma; glioma; silicon nanoparticles; transferrin
Impact:09.429 (2021)
Funding Information:Commonwealth Scientific and Industrial Research Organisation (CSIRO)
DDC classes:600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin, Gesundheit
Open Access:Open Access
Signature:INM 2021/030
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International