Volltext-Downloads (blau) und Frontdoor-Views (grau)

Surface-assisted laser desorption/ionization mass spectrometry using ordered silicon nanopillar arrays

  • Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is ideally suited for the high-throughput analysis of small molecules in bodily fluids (e.g. saliva, urine, and blood plasma). A key application for this technique is the testing of drug consumption in the context of workplace, roadside, athlete sports and anti-addictive drug compliance. Here, we show that vertically-aligned ordered silicon nanopillar (SiNP) arrays fabricated using nanosphere lithography followed by metal-assisted chemical etching (MACE) are suitable substrates for the SALDI-MS detection of methadone and small peptides. Porosity, length and diameter are fabrication parameters that we have explored here in order to optimize analytical performance. We demonstrate the quantitative analysis of methadone in MilliQ water down to 32 ng mL-1. Finally, the capability of SiNP arrays to facilitate the detection of methadone in clinical samples is also demonstrated.

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar


Document Type:Article
Author:Hashim Z. AlhmoudORCiD, Taryn M. GuinanORCiD, Roey ElnathanORCiD, Hilton KobusORCiD, Nicolas H. VoelckerORCiD
Parent Title (English):Analyst
First Page:5999
Last Page:6009
Year of first Publication:2014
Release Date:2022/08/26
Impact:04.107 (2014)
DDC classes:500 Naturwissenschaften und Mathematik / 540 Chemie
Open Access:Open Access
Signature:INM 2014/104
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International