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Digital research data: from analysis of existing standards to a scientific foundation for a modular metadata schema in nanosafety

  • Assessing the safety of engineered nanomaterials (ENMs) is an interdisciplinary and complex process producing huge amounts of information and data. To make such data and metadata reusable for researchers, manufacturers, and regulatory authorities, there is an urgent need to record and provide this information in a structured, harmonized, and digitized way. RESULTS: This study aimed to identify appropriate description standards and quality criteria for the special use in nanosafety. There are many existing standards and guidelines designed for collecting data and metadata, ranging from regulatory guidelines to specific databases. Most of them are incomplete or not specifically designed for ENM research. However, by merging the content of several existing standards and guidelines, a basic catalogue of descriptive information and quality criteria was generated. In an iterative process, our interdisciplinary team identified deficits and added missing information into a comprehensive schema. Subsequently, this overview was externally evaluated by a panel of experts during a workshop. This whole process resulted in a minimum information table (MIT), specifying necessary minimum information to be provided along with experimental results on effects of ENMs in the biological context in a flexible and modular manner. The MIT is divided into six modules: general information, material information, biological model information, exposure information, endpoint read out information and analysis and statistics. These modules are further partitioned into module subdivisions serving to include more detailed information. A comparison with existing ontologies, which also aim to electronically collect data and metadata on nanosafety studies, showed that the newly developed MIT exhibits a higher level of detail compared to those existing schemas, making it more usable to prevent gaps in the communication of information. CONCLUSION: Implementing the requirements of the MIT into e.g., electronic lab notebooks (ELNs) would make the collection of all necessary data and metadata a daily routine and thereby would improve the reproducibility and reusability of experiments. Furthermore, this approach is particularly beneficial regarding the rapidly expanding developments and applications of novel non-animal alternative testing methods.

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Document Type:Article
Author:Linda ElberskirchORCiD, Kunigunde Binder, Norbert RieflerORCiD, Adriana SofrankoORCiD, Julia LiebingORCiD, Christian Bonatto MinellaORCiD, Lutz MädlerORCiD, Matthias RazumORCiD, Christoph van ThrielORCiD, Klaus UnfriedORCiD, Roel P. F. SchinsORCiD, Annette KraegelohORCiD
Parent Title (English):Particle and fibre toxicology
First Page:1
Last Page:19
Year of Completion:2022
Date of first Publication:2022/01/05
Release Date:2022/05/12
Tag:Data re-use; metadata; minium information standard; nanomaterial; research data management
Impact:09.112 (2021)
Funding Information:German Federal Ministry of Education and Research (BMBF) under FKZ 16QK07; Project DEAL
Groups:Nano Zell Interaktionen
DDC classes:000 Allgemeines, Informatik, Informationswissenschaft / 020 Bibliotheks- und Informationswissenschaft
Open Access:Open Access
Signature:INM 2021/016
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International