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Exogenous supply of Hsp47 triggers fibrillar collagen deposition in skin cell cultures in vitro

  • Collagen is a structural protein that provides mechanical stability and defined architectures to skin. In collagen-based skin disorders this stability is lost, either due to mutations in collagens or in the chaperones involved in collagen assembly. This leads to chronic wounds, skin fragility, and blistering. Existing approaches to treat such conditions rely on administration of small molecules to simulate collagen production, like 4-phenylbutyrate (4-PBA) or growth factors like TGF-β. However, these molecules are not specific for collagen synthesis, and result in unsolicited side effects. Hsp47 is a collagen-specific chaperone with a major role in collagen biosynthesis. Expression levels of Hsp47 correlate with collagen deposition. This article explores the stimulation of collagen deposition by exogenously supplied Hsp47 (collagen specific chaperone) to skin cells, including specific collagen subtypes quantification.
Document Type:Article
Author:Essak S. KhanORCiD, Shrikrishnan SankaranORCiD, Lorena Llontop, Aránzazu del Campo BécaresORCiD
Parent Title (English):BMC Molecular and Cell Biology
First Page:22
Year of first Publication:2020
Release Date:2022/08/31
Tag:Collagen deposition; Collagen fibrils; Extracellular matrix; Hsp47
Impact:02.033 (2020)
Funding Information:Deutsche Forschung Gemeinschaft (SFB 1027)
Groups:Dynamische Biomaterialien
Bioprogrammierbare Materialien
DDC classes:500 Naturwissenschaften und Mathematik / 570 Biowissenschaften, Biologie
Open Access:Open Access
Signature:INM 2020/042
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International