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How Structured Metadata Acquisition Contributes to the Reproducibility of Nanosafety Studies: Evaluation by a Round-Robin Test

  • It has been widely recognized that nanosafety studies are limited in reproducibility, caused by missing or inadequate information and data gaps. Reliable and comprehensive studies should be performed supported by standards or guidelines, which need to be harmonized and usable for the multidisciplinary field of nanosafety research. The previously described minimal information table (MIT), based on existing standards or guidelines, represents one approach towards harmonization. Here, we demonstrate the applicability and advantages of the MIT by a round-robin test. Its modular structure enables describing individual studies comprehensively by a combination of various relevant aspects. Three laboratories conducted a WST-1 cell viability assay using A549 cells to analyze the effects of the reference nanomaterials NM101 and NM110 according to predefined (S)OPs. The MIT contains relevant and defined descriptive information and quality criteria and thus supported the implementation of the round-robin test from planning, investigation to analysis and data interpretation. As a result, we could identify sources of variability and justify deviating results attributed to differences in specific procedures. Consequently, the use of the MIT contributes to the acquisition of reliable and comprehensive datasets and therefore improves the significance and reusability of nanosafety studies.

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Document Type:Article
Author:Linda ElberskirchORCiD, Adriana SofrankoORCiD, Julia LiebingORCiD, Norbert RieflerORCiD, Kunigunde Binder, Christian Bonatto MinellaORCiD, Matthias RazumORCiD, Lutz MädlerORCiD, Klaus UnfriedORCiD, Roel P. F. SchinsORCiD, Annette KraegelohORCiD, Christoph van ThrielORCiD
Parent Title (English):Nanomaterials
First Page:1053
Year of Completion:2022
Date of first Publication:2022/03/24
Release Date:2022/05/12
Tag:dexcription standards; interlaboratory comparison; minimal information; quality criteria
Impact:05.719 (2021)
Funding Information:German Federal Ministry of Education and Research (BMBF) under FKZ 16QK07
Groups:Nano Zell Interaktionen
DDC classes:000 Allgemeines, Informatik, Informationswissenschaft / 020 Bibliotheks- und Informationswissenschaft
Open Access:Open Access
Signature:INM 2022/040
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International