A Self-Adhesive Elastomeric Wound Scaffold for Sensitive Adhesion to Tissue
- Pressure sensitive adhesives based on silicone materials are used particularly for skin adhesion, e.g., the fixation of electrocardiogram (ECG) electrodes or wound dressings. However, adhesion to sensitive tissue structures is not sufficiently addressed due to the risk of damage or rupture. We propose an approach in which a poly-(dimethylsiloxane) (PDMS)-based soft skin adhesive (SSA) acts as cellular scaffold for wound healing. Due to the intrinsically low surface free energy of silicone elastomers, functionalization strategies are needed to promote the attachment and spreading of eukaryotic cells. In the present work, the effect of physical adsorption of three different proteins on the adhesive properties of the soft skin adhesive was investigated. Fibronectin adsorption slightly affects adhesion but significantly improves the cellular interaction of L929 murine fibroblasts with the polymeric surface. Composite films were successfully attached to explanted tympanic membranes. This demonstrates the potential of protein functionalized SSA to act as an adhesive scaffold in delicate biomedical applications
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| Document Type: | Article |
|---|---|
| Author: | Silviya Boyadzhieva, Katharina SorgORCiD, Martin Danner, Sarah FischerORCiD, René HenselORCiD, Bernhard Schick, Gentiana Wenzel, Eduard ArztORCiD, Klaus Kruttwig |
| URN: | urn:nbn:de:bsz:291:415-2968 |
| URL: | https://www.mdpi.com/2073-4360/11/6/942 |
| URL: | https://europepmc.org/articles/PMC6630294 |
| DOI: | https://doi.org/10.3390/polym11060942 |
| ISSN: | 2073-4360 |
| Parent Title (English): | Polymers |
| Volume: | 11 |
| Issue: | 6 |
| Pagenumber: | 942 |
| Language: | English |
| Year of first Publication: | 2019 |
| Release Date: | 2022/11/18 |
| Tag: | PDMS; PSA; cells; protein coating; scaffold; scaffold material; self-adhesive; soft scin adhesive; tympanic membrane; wound dressing |
| Impact: | 03.426 (2019) |
| Funding Information: | European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement No. 340929 |
| Scientific Units: | Functional Microstructures |
| Open Access: | Open Access |
| Signature: | INM 2019/084 |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
