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Adhesion and Cellular Compatibility of Silicone-Based Skin Adhesives

  • Pressure-sensitive adhesives based on silicone materials have emerging potential as adhesives in healthcare products, in particular for gentle skin adhesives. To this end, adhesion to rough skin and biocompatibility are crucial factors for a successful implementation. In this study, the mechanical, adhesive, and biological properties of the two-component poly(dimethylsiloxane) Soft Skin Adhesive MG 7-9800 (SSA, Dow Corning) have been investigated and compared to Sylgard 184. Different mixing ratios of SSA's components allow for tuning of the shear modulus, thereby modifying the adhesive properties of the polymer. To give a comprehensive insight, the authors have analyzed the interplay between pull-off stress, adhesion energy, and stretch of the adhesive films on smooth and rough surfaces. The focus is placed on the effects of substrate roughness and on low pressure oxygen plasma treatment of the adhesive films. SSA shows superior biocompatibility in in vitro cell culture experiments. High pull-off stresses in the range of 3 N cm−2 on a rough surface are achieved, promising broad application spectra for SSA-based healthcare products.

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Document Type:Article
Author:Sarah FischerORCiD, Klaus Kruttwig, Vera Bandmann, René HenselORCiD, Eduard ArztORCiD
Parent Title (English):Macromolecular Materials and Engineering
First Page:1600526
Year of first Publication:2017
Release Date:2022/11/18
Tag:biocompatibility; oxygen plasma treatment; poly(dimethylsiloxane); pressure-sensitive adhesives; roughness
Impact:02.690 (2017)
Funding Information:European Research Council. Grant Number: 340929; European Union's Seventh Framework Programme. Grant Number: FP/2007-2013
Groups:Funktionelle Mikrostrukturen
Open Access:Open Access
Signature:INM 2017/026
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International