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Bioinspired polydimethylsiloxane-based composites with high shear resistance against wet tissue

  • Patterned microstructures represent a potential approach for improving current wound closure strategies. Microstructures can be fabricated by multiple techniques including replica molding of soft polymer-based materials. However, polymeric microstructures often lack the required shear resistance with tissue needed for wound closure. In this work, scalable microstructures made from composites based on polydimethylsiloxane (PDMS) were explored to enhance the shear resistance with wet tissue. To achieve suitable mechanical properties, PDMS was reinforced by incorporation of polyethylene (PE) particles into the pre-polymer and by coating PE particle reinforced substrates with parylene. The reinforced microstructures showed a 6-fold enhancement, the coated structures even a 13-fold enhancement in Young ׳ s modulus over pure PDMS. Shear tests of mushroom-shaped microstructures (diameter 450 µm, length 1 mm) against chicken muscle tissue demonstrate first correlations that will be useful for future design of wound closure or stabilization implants.

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Document Type:Article
Author:Sarah FischerORCiD, Oren Levy, Elmar KronerORCiD, René HenselORCiD, Jeffrey M. Karp, Eduard ArztORCiD
Parent Title (English):Journal of the Mechanical Behavior of Biomedical Materials
First Page:87
Last Page:95
Year of first Publication:2016
Release Date:2022/11/18
Tag:bioinspired; composite; polydimethylsiloxan (PDMS); shear resistance; wound closure
Impact:03.110 (2016)
Funding Information:European Research Council under the European Union׳s Seventh Framework Programme (FP/2007-2013)/ERC Grant Agreement no. 340929; NIH grant GM086433
Scientific Units:Functional Microstructures
Open Access:Open Access
Signature:INM 2016/017
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International