The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
- We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.
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| Document Type: | Article |
|---|---|
| Author: | Beatrice Formicola, Roberta Dal Magro, Carlos V. Montefusco-PereiraORCiD, Claus-Michael LehrORCiD, Marcus Koch, Laura RussoORCiD, Gianvito Grasso, Marco A. DeriuORCiD, Andrea DananiORCiD, Sandrine Bourdoulous, Francesca ReORCiD |
| URN: | urn:nbn:de:bsz:291:415-3423 |
| DOI: | https://doi.org/10.1186/s12951-019-0546-3 |
| ISSN: | 1477-3155 |
| Parent Title (English): | Journal of Nanobiotechnology |
| Volume: | 17 |
| Issue: | 1 |
| First Page: | 115_1 |
| Last Page: | 115_7 |
| Language: | English |
| Year of first Publication: | 2019 |
| Release Date: | 2022/11/18 |
| Tag: | blood-brain barrier; brain; chlorotoxin; doxorubicin; drug delivery; glioblastoma; liposomes; nanoparticles |
| Impact: | 06.518 (2019) |
| Funding Information: | This work was partially supported by the Grant JPND-COFUND_FP-829-031 (2016-2019) to FR and by H2020-MSCA-ITN-2014_grant agreement no. 642028 to LR. |
| Scientific Units: | Physical Analytics |
| Open Access: | Open Access |
| Signature: | INM 2019/167 |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
