Visualisation of HER2 homodimers in single cells from HER2 overexpressing primary formalin fixed paraffin embedded tumour tissue
- HER2 is considered as one of the most important, predictive biomarkers in oncology. The diagnosis of HER2 positive cancer types such as breast- and gastric cancer is usually based on immunohistochemical HER2 staining of tumour tissue. However, the current immunohistochemical methods do not provide localized information about HER2’s functional state. In order to generate signals leading to cell growth and proliferation, the receptor spontaneously forms homodimers, a process that can differ between individual cancer cells.
| Document Type: | Article |
|---|---|
| Author: | Diana B. PeckysORCiD, Daniela Hirsch, Timo Gaiser, Niels de JongeORCiD |
| URN: | urn:nbn:de:bsz:291:415-4161 |
| DOI: | https://doi.org/10.1186/s10020-019-0108-z |
| ISSN: | 1528-3658 |
| Parent Title (English): | Molecular Medicine |
| Volume: | 25 |
| Issue: | 1 |
| Pagenumber: | 42 |
| Language: | English |
| Year of first Publication: | 2019 |
| Release Date: | 2022/11/18 |
| Impact: | 04.427 (2019) |
| Funding Information: | Deutsche Forschungsgemeinschaft (sfb1027) Else Kröner-Fresenius-Stiftung (HERe) Deutsche Krebshilfe (70113500) |
| Scientific Units: | Innovative Electron Microscopy |
| Open Access: | Open Access |
| Signature: | INM 2019/123 |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
