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Targeted T1 Magnetic Resonance Imaging Contrast Enhancement with Extraordinarily Small CoFe2O4 Nanoparticles

  • Extraordinarily small (2.4 nm) cobalt ferrite nanoparticles (ESCIoNs) were synthesized by a one-pot thermal decomposition approach to study their potential as magnetic resonance imaging (MRI) contrast agents. Fine size control was achieved using oleylamine alone, and annular dark-field scanning transmission electron microscopy revealed highly crystalline cubic spinel particles with atomic resolution. Ligand exchange with dimercaptosuccinic acid rendered the particles stable in physiological conditions with a hydrodynamic diameter of 12 nm. The particles displayed superparamagnetic properties and a low r2/r1 ratio suitable for a T1 contrast agent. The particles were functionalized with bile acid, which improved biocompatibility by significant reduction of reactive oxygen species generation and is a first step toward liver-targeted T1 MRI. Our study demonstrates the potential of ESCIoNs as T1 MRI contrast agents.

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Document Type:Article
Author:Dominique PichéORCiD, Isabella Tavernaro, Jana Fleddermann, Juan G. LozanoORCiD, Aakash Varambhia, Mahon L. Maguire, Marcus Koch, Tomofumi Ukai, Armando J. Hernández Rodríguez, Lewys JonesORCiD, Frank Dillon, Israel Reyes Molina, Mai Mitzutani, Evelio R. González DalmauORCiD, Toru Maekawa, Peter D. Nellist, Annette KraegelohORCiD, Nicole Grobert
Parent Title (English):ACS Applied Materials & Interfaces
First Page:6724
Last Page:6740
Publisher:American Chemical Society
Year of first Publication:2019
Release Date:2022/11/18
Impact:08.758 (2019)
Groups:Nano Zell Interaktionen
Physikalische Analytik
Open Access:Open Access
Signature:INM 2019/042
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International