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3D Printed Tubular Scaffolds with Massively Tailorable Mechanical Behavior

  • Melt electrowriting (MEW) is a promising additive manufacturing technique for tissue scaffold biofabrication. Successful application of MEW scaffolds requires strictly controlled mechanical behavior. This requires scaffold geometry be optimized to match native tissue properties while simultaneously supporting cell attachment and proliferation. The objective of this work is to investigate how geometric properties can be exploited to massively tailor the mechanical behavior of tubular crosshatch scaffolds. An experimentally validated finite element (FE) model is developed and 441 scaffold geometries are investigated under tension, compression, bending, and radial loading. A range of pore areas (4–150 mm2) and pore angles (11°–134°) are investigated. It is found that scaffold mechanical behavior is massively tunable through the control of these simple geometric parameters. Across the ranges investigated, scaffold stiffness varies by a factor of 294× for tension, 204× for compression, 231× for bending, and 124× for radial loading. Further, it is discussed how these geometric parameters can be simultaneously tuned for different biomimetic material applications. This work provides critical insights into scaffold design to achieve biomimetic mechanical behavior and provides an important tool in the development of biomimetic tissue engineered constructs.

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Metadaten
Document Type:Article
Author:Edmund PickeringORCiD, Naomi C. PaxtonORCiD, Arixin BoORCiD, Bridget O’Connell, Mitchell King, Maria A WoodruffORCiD
URN:urn:nbn:de:bsz:291:415-4215
DOI:https://doi.org/10.1002/adem.202200479
ISSN:1438-1656
Parent Title (English):Advanced Engineering Materials
Volume:24
Issue:11
Pagenumber:2200479
Language:English
Year of first Publication:2022
Release Date:2022/11/18
Tag:additive manufacturing; biomimetic; finite elements; mechanical testing; melt electrowriting; scaffolds
Impact:04.122 (2021)
Funding Information:Advance Queensland Industry Research Fellowship(AQIRF2020)
Scientific Units:Structure Formation
Open Access:Open Access
Signature:INM 2022/078
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International