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Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles

  • Messenger RNA (mRNA) has gained remarkable attention as an alternative to DNA-based therapies in biomedical research. A variety of biodegradable nanoparticles (NPs) has been developed including lipid-based and polymer-based systems for mRNA delivery. However, both systems still lack in achieving an efficient transfection rate and a detailed understanding of the mRNA transgene expression kinetics. Therefore, quantitative analysis of the time-dependent translation behavior would provide a better understanding of mRNA’s transient nature and further aid the enhancement of appropriate carriers with the perspective to generate future precision nanomedicines with quick response to treat various diseases.

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Metadaten
Document Type:Article
Author:Hanzey Yasar, Alexander Biehl, Chiara De Rossi, Marcus Koch, Xabier MurgiaORCiD, Brigitta LoretzORCiD, Claus-Michael LehrORCiD
URN:urn:nbn:de:bsz:291:415-4996
DOI:https://doi.org/10.1186/s12951-018-0401-y
ISSN:1477-3155
Parent Title (English):Journal of Nanobiotechnology
Volume:16
Issue:1
Pagenumber:72
Language:English
Year of first Publication:2018
Release Date:2022/11/18
Impact:05.345 (2018)
Scientific Units:Physical Analytics
Open Access:Open Access
Signature:INM 2018/097
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International