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Enantiomer-selective magnetization of conglomerates for quantitative chiral separation

  • Selective crystallization represents one of the most economical and convenient methods to provide large-scale optically pure chiral compounds. Although significant development has been achieved since Pasteur’s separation of sodium ammonium tartrate in 1848, this method is still fundamentally low efficient (low transformation ratio or high labor). Herein, we describe an enantiomer-selective-magnetization strategy for quantitatively separating the crystals of conglomerates by using a kind of magnetic nano-splitters. These nano-splitters would be selectively wrapped into the S-crystals, leading to the formation of the crystals with different physical properties from that of R-crystals. As a result of efficient separation under magnetic field, high purity chiral compounds (99.2 ee% for R-crystals, 95.0 ee% for S-crystals) can be obtained in a simple one-step crystallization process with a high separation yield (95.1%). Moreover, the nano-splitters show expandability and excellent recyclability. We foresee their great potential in developing chiral separation methods used on different scales.

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Document Type:Article
Author:Xichong Ye, Jiaxi CuiORCiD, Bowen Li, Na Li, Rong Wang, Zijia Yan, Junyan Tan, Jie Zhang, Xinhua Wan
Parent Title (English):Nature Communications
First Page:1964
Year of first Publication:2019
Release Date:2022/11/18
Impact:12.121 (2019)
Funding Information:National Natural Science Foundation of China (Nos. 51833001 and 21674002); Leibniz Research Cluster (031A360D)
Open Access:Open Access
Signature:INM 2019/068
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International