High glucose distinctively regulates Ca2+ influx in cytotoxic T lymphocytes upon target recognition and thapsigargin stimulation
- In CTLs: High glucose-culture enhances thapsigargin-induced SOCE but decreases target recognition-induced Ca2+ influx. High glucose-culture regulates expression of ORAIs and STIMs without affecting glucose uptake. More high glucose-cultured CTLs are prone to necrosis after execution of killing.
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| Document Type: | Article |
|---|---|
| Author: | Huajiao Zou, Wenjuan Yang, Gertrud Schwär, Renping ZhaoORCiD, Dalia AlansaryORCiD, Deling Yin, Eva C. SchwarzORCiD, Barbara A. NiemeyerORCiD, Bin QuORCiD |
| URN: | urn:nbn:de:bsz:291:415-5106 |
| DOI: | https://doi.org/10.1002/eji.202048577 |
| ISSN: | 0014-2980 |
| Parent Title (English): | European Journal of Immunology |
| Volume: | 50 |
| Issue: | 12 |
| First Page: | 2095 |
| Last Page: | 2098 |
| Language: | English |
| Year of first Publication: | 2020 |
| Release Date: | 2022/11/18 |
| Impact: | 05.0532 (2020) |
| Funding Information: | Deutsche Forschungsgemeinschaft Forschungsgroßgeräte. Grant Number: INST 256/423-1 FUGG Leibniz-Gemeinschaft |
| Scientific Units: | Fellow |
| Open Access: | Open Access |
| Signature: | INM 2020/101 |
| Licence (German): |  Creative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International |
