Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion & Assembly
- Hsp47 is a chaperone protein with a fundamental role in the folding, stability and intracellular transport of procollagen triple helices. A light-responsive Hsp47 recombinant protein, engineered to control in situ the production and assembly of cellular collagen is here demonstrated. This novel light-driven tool enables unprecedented fundamental studies of collagen biosynthesis and associated diseases.
| Document Type: | Preprint |
|---|---|
| Author: | Essak S. KhanORCiD, Shrikrishnan SankaranORCiD, Julieta I. PaezORCiD, Christina Muth, Mitchell K. L. Han, Aránzazu del Campo BécaresORCiD |
| URN: | urn:nbn:de:bsz:291:415-5336 |
| DOI: | https://doi.org/10.26434/chemrxiv.6964703.v3 |
| Parent Title (English): | ChemRxiv |
| Edition: | Version 3 |
| First Page: | 1 |
| Last Page: | 32 |
| Language: | English |
| Date of first Publication: | 2018/10/18 |
| Release Date: | 2022/12/21 |
| Tag: | Hsp47; KDEL receptor mediated endocytosis; biological activity; collagen; photoactivation |
| DDC classes: | 500 Naturwissenschaften und Mathematik / 540 Chemie |
| Open Access: | Open Access |
| Signature: | INM 2018/084_preprint |
| Licence (German): |  Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |
