Volltext-Downloads (blau) und Frontdoor-Views (grau)

Photoactivatable Hsp47: A Tool to Control and Regulate Collagen Secretion & Assembly

  • Hsp47 is a chaperone protein with a fundamental role in the folding, stability and intracellular transport of procollagen triple helices. A light-responsive Hsp47 recombinant protein, engineered to control in situ the production and assembly of cellular collagen is here demonstrated. This novel light-driven tool enables unprecedented fundamental studies of collagen biosynthesis and associated diseases.

Download full text files

Export metadata

Additional Services

Share in Twitter Search Google Scholar


Document Type:Preprint
Author:Essak S. KhanORCiD, Shrikrishnan SankaranORCiD, Julieta I. PaezORCiD, Christina Muth, Mitchell K. L. Han, Aránzazu del Campo BécaresORCiD
Parent Title (English):ChemRxiv
Edition:Version 3
First Page:1
Last Page:32
Date of first Publication:2018/10/18
Release Date:2022/12/21
Tag:Hsp47; KDEL receptor mediated endocytosis; biological activity; collagen; photoactivation
Groups:Dynamische Biomaterialien
DDC classes:500 Naturwissenschaften und Mathematik / 540 Chemie
Open Access:Open Access
Signature:INM 2018/084_preprint
Licence (German):License LogoCreative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International