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Increasing Antibacterial Efficiency of Cu Surfaces by targeted Surface Functionalization via Ultrashort Pulsed Direct Laser Interference Patterning

  • Copper (Cu) exhibits great potential for application in the design of antimicrobial contact surfaces aiming to reduce pathogenic contamination in public areas as well as clinically critical environments. However, current application perspectives rely purely on the toxic effect of emitted Cu ions, without considering influences on the interaction of pathogenic microorganisms with the surface to enhance antimicrobial efficiency. In this study, it is investigated on how antibacterial properties of Cu surfaces against Escherichia coli can be increased by tailored functionalization of the substrate surface by means of ultrashort pulsed direct laser interference patterning (USP-DLIP). Surface patterns in the scale range of single bacteria cells are fabricated to purposefully increase bacteria/surface contact area, while parallel modification of the surface chemistry allows to involve the aspect of surface wettability into bacterial attachment and the resulting antibacterial effectivity. The results exhibit a delicate interplay between bacterial adhesion and the expression of antibacterial properties, where a reduction of bacterial cell viability of up to 15-fold can be achieved for E. coli on USP-DLIP surfaces in comparison to smooth Cu surfaces. Thereby, it can be shown how the antimicrobial properties of copper surfaces can be additionally enhanced by targeted surface functionalization.

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Document Type:Article
Author:Daniel W. Müller, Sarah LößleinORCiD, Emmanuel TerriacORCiD, Kristina BrixORCiD, Katharina SiemsORCiD, Ralf MoellerORCiD, Ralf KautenburgerORCiD, Frank MücklichORCiD
Parent Title (English):Advanced Materials Interfaces
First Page:2001656
Year of first Publication:2021
Release Date:2022/08/08
Tag:antimicrobial copper surfaces; laser surface structuring; ultrashort pulsed direct laser interference patterning
Impact:06.389 (2021)
Funding Information:German Research Foundation. Grant Numbers: 415956642, SFB1027 German Aerospace Center – Space Administration. Grant Number: 50WB1930
Groups:Dynamische Biomaterialien
DDC classes:500 Naturwissenschaften und Mathematik / 570 Biowissenschaften, Biologie
Open Access:Open Access
Signature:INM 2021/156
Licence (German):License LogoCreative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International