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Thiol-methylsulfone-based Hydrogels for Cell Encapsulation: Reactivity Optimization of Aryl-methylsulfone Substrate for Fine-tunable Gelation Rate and Improved Stability

  • We present novel thiol-methylsulfone hydrogels for cell encapsulation applications. The reactivity of the methylsulfonyl reactive partner has been optimized to improve the properties of the derived hydrogels for cell encapsulation.

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Metadaten
Document Type:Preprint
Author:Julieta I. PaezORCiD, Adrián de Miguel-Jimenez, Rocío Valbuena Mendoza, Aditi Rathore, Minye Jin, Alisa Gläser, Samuel Pearson, Aránzazu del Campo BécaresORCiD
URN:urn:nbn:de:bsz:291:415-845
DOI:https://doi.org/10.26434/chemrxiv.14115404.v1
Parent Title (English):chemRxiv
Language:English
Date of first Publication:2021/02/26
Release Date:2022/08/09
Tag:PEG hydrogels; cell encapsulation; gel stability; thiol-arylmethylsulfone; water-based crosslinking reactions
Funding Information:Deutsche Forschungsgemeinschaft (DFG, Project no. 422041745); Deutscher Akademischer Austauschdienst (DAAD, Exchange Internship Program); European Union’s Horizon 2020 research and innovation programme under the FET PROACTIVE grant agreement no. 731957 (Mechano-Control)
Scientific Units:Dynamical Biomaterials
DDC classes:500 Naturwissenschaften und Mathematik / 570 Biowissenschaften, Biologie
Open Access:Open Access
Signature:INM 2021/018_preprint
Licence (German):License LogoCreative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International