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Self-Adhesive Silicone Microstructures for the Treatment of Tympanic Membrane Perforations

  • Inspired by the gecko foot, polymeric microstructures have demonstrated reliable dry adhesion to both stiff objects and sensitive surfaces such as skin. Microstructured silicone patches are here proposed for the treatment of tympanic membrane perforations with the aim of serving as an alternative for current surgical procedures that require anesthesia and ear canal packing. Sylgard 184 PDMS micropillars of 20 µm in diameter and 60 µm in length are topped by a Soft Skin Adhesive (SSA) MG7-1010 terminal layer, of about 25 µm thickness. The adhesion is evaluated by specially designed tack tests against explanted murine eardrums and, for comparison, against a rigid substrate. Functional effects are evaluated using auditory brainstem responses (ABR) and distortion product otoacoustic emissions (DPOAE). The adhesion strength of the microstructure and unstructured controls to explanted murine tympanic membranes is comparable (typically 12 kPa), but the microstructured patches are easier to handle by the surgeon. For the first time, partial recovery of hearing performance is measured immediately after patch application. The novel patches adhere without the need for further fixation, removing the need for ear canal packing. The proposed material design holds great promise for improving clinical treatments of tympanic membrane perforations

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Metadaten
Document Type:Article
Author:Gabriela Moreira LanaORCiD, Katharina SorgORCiD, Gentiana Ioana WenzelORCiD, Dietmar HeckerORCiD, René HenselORCiD, Bernhard Schick, Klaus Kruttwig, Eduard ArztORCiD
URN:urn:nbn:de:bsz:291:415-898
DOI:https://doi.org/10.1002/anbr.202100057
Parent Title (English):Advanced NanoBiomed Research
Volume:1
First Page:2100057
Language:English
Year of first Publication:2021
Release Date:2022/08/09
Tag:Distortion product otoacoustic missions; Microstructured adhesives; Silicone patch; Tympanic membrane perforation
Funding Information:H2020 European Research Council. Grant Number: 842613
Scientific Units:Functional Microstructures
DDC classes:600 Technik, Medizin, angewandte Wissenschaften / 610 Medizin, Gesundheit
Open Access:Open Access
Signature:INM 2021/075
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International