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SEC14-GOLD protein PATELLIN2 binds IRON-REGULATED TRANSPORTER1 linking root iron uptake to vitamin E

  • Organisms require micronutrients, and Arabidopsis (Arabidopsis thaliana) IRON-REGULATED TRANSPORTER1 (IRT1) is essential for iron (Fe2+) acquisition into root cells. Uptake of reactive Fe2+ exposes cells to the risk of membrane lipid peroxidation. Surprisingly little is known about how this is avoided. IRT1 activity is controlled by an intracellular variable region (IRT1vr) that acts as a regulatory protein interaction platform. Here, we describe that IRT1vr interacted with peripheral plasma membrane SEC14-Golgi dynamics (SEC14-GOLD) protein PATELLIN2 (PATL2). SEC14 proteins bind lipophilic substrates and transport or present them at the membrane. To date, no direct roles have been attributed to SEC14 proteins in Fe import. PATL2 affected root Fe acquisition responses, interacted with ROS response proteins in roots, and alleviated root lipid peroxidation. PATL2 had high affinity in vitro for the major lipophilic antioxidant vitamin E compound α-tocopherol. Molecular dynamics simulations provided insight into energetic constraints and the orientation and stability of the PATL2-ligand interaction in atomic detail. Hence, this work highlights a compelling mechanism connecting vitamin E with root metal ion transport at the plasma membrane with the participation of an IRT1-interacting and α-tocopherol-binding SEC14 protein.
Metadaten
Document Type:Article
Author:Jannik HornbergsORCiD, Karolin Montag, Jennifer LoschwitzORCiD, Inga MohrORCiD, Gereon PoschmannORCiD, Anika Schnake, Regina GratzORCiD, Tzvetina BrumbarovaORCiD, Monique EutebachORCiD, Kalina AngrandORCiD, Claudia Fink-Straube, Kai StühlerORCiD, Jürgen ZeierORCiD, Laura HartmannORCiD, Birgit StrodelORCiD, Rumen IvanovORCiD, Petra BauerORCiD
URN:urn:nbn:de:bsz:291:415-6050
DOI:https://doi.org/10.1093/plphys/kiac563
Parent Title (English):Plant physiology
Volume:192
First Page:504
Last Page:526
Language:English
Year of first Publication:2023
Release Date:2023/05/10
Impact:06.50 (2023)
Funding Information:Deutsche Forschungsgemeinschaft SFB 1208, project B05 (P.B.), A07 (B.S.), A11 (L.H.), Z1 (K.S.)
Scientific Units:Chemical Analytics
DDC classes:500 Naturwissenschaften und Mathematik / 570 Biowissenschaften, Biologie
Open Access:Open Access
Signature:INM 2023/040
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International