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Recombinant phage coated 1D Al 2 O 3 nanostructures for controlling the adhesion and proliferation of endothelial cells

  • A novel synthesis of a nanostructured cell adhesive surface is investigated for future stent developments. One-dimensional (1D) Al 2 O 3 nanostructures were prepared by chemical vapor deposition of a single source precursor. Afterwards, recombinant filamentous bacteriophages which display a short binding motif with a cell adhesive peptide (RGD) on p3 and p8 proteins were immobilized on these 1D Al 2 O 3 nanostructures by a simple dip-coating process to study the cellular response of human endothelial EA hy.926. While the cell density decreased on as-deposited 1D Al 2 O 3 nanostructures, we observed enhanced cell proliferation and cell-cell interaction on recombinant phage overcoated 1D Al 2 O 3 nanostructures. The recombinant phage overcoating also supports an isotropic cell spreading rather than elongated cell morphology as we observed on as-deposited Al 2 O 3 1D nanostructures.

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Document Type:Article
Author:Juseok Lee, Hojeong Jeon, Ayman HaidarORCiD, Hashim Abdul-Khaliq, Michael Veith, Oral C. AktasORCiD, Youngjun Kim
Parent Title (English):BioMed Research International
First Page:909807
Year of first Publication:2015
Release Date:2022/11/18
Impact:02.134 (2015)
Funding Information:Korea-EU Joint Research Program 2014 of the National Research Council of Science and Technology (NST)) between Leibniz Institute for New Materials and Korea Institute of Science and Technology Europe
Open Access:Open Access
Signature:INM 2015/048
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International